Article
Evolutionary remodeling of global regulatory networks during long-term bacterial adaptation to human hosts.
Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013
Damkiær Søren, Yang Lei, Molin Søren, Jelsbak Lars
Abstract excerpt
The genetic basis of bacterial adaptation to a natural environment has been investigated in a highly successful Pseudomonas aeruginosa lineage (DK2) that evolved within the airways of patients with cystic fibrosis (CF) for more than 35 y. During evolution in the CF airways, the DK2 lineage underwent substantial phenotypic changes, which correlated with temporal fixation of specific mutations in the genes mucA...
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