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Article

Structure-based screening of inhibitors against KPC-2: designing potential drug candidates against multidrug-resistant bacteria.

Journal of biomolecular structure & dynamics - 1 Jan 2014

Danishuddin Mohd, Khan Arbab, Faheem Mohammad, Kalaiarasan Ponnusamy, Hassan Baig Mohd, Subbarao Naidu, Khan Asad U

Abstract excerpt

KPC-2 β-lactamase demonstrates a wide substrate spectrum that includes carbapenamases, oxyimino-cephalosporins, and cephamycins. In addition, strains harboring KPC-type β-lactamases are often identified as resistant to standard β-lactamase inhibitors. Thus, KPC-2 carbapenems present a significant clinical challenge, as the mechanistic bases for KPC-2-associated phenotypes remain mysterious. Inhibiting the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23600675
DOI: 10.1080/07391102.2013.789988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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