Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

2-Methoxyjuglone Induces Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells and Exhibits in Vivo Antitumor Activity in a H22 Mouse Hepatocellular Carcinoma Model

18 Apr 2013

Abstract excerpt

In order to discover anticancer agents from natural sources, an ethanol-soluble extract of the root bark of Juglans cathayensis was investigated and showed cytotoxic effects against various human cancer cell lines. A subsequent phytochemical study on the EtOAc-soluble fraction determined 2-methoxyjuglone (1) as one of the main active constituents. Compound 1 was shown to be cytotoxic against HepG2 cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bioactive Compounds and Antitumor Agents
Share to Cancer, Hypoxia, and Metabolism
Share to Nitric Oxide and Endothelin Effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23597099
DOI: 10.1021/np400025b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

2-Methoxyjuglone Induces Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells and Exhibits in Vivo Antitumor Activity in a H22 Mouse Hepatocellular Carcinoma ModelPMID 23597099Read ↗

A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cellsSemantic proximity Read ↗

A novel ruthenium complex with xanthoxylin induces S-phase arrest and causes ERK1/2-mediated apoptosis in HepG2 cells through a p53-independent pathwaySemantic proximity Read ↗

Momordica charantiaExtract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent PathwaysSemantic proximity Read ↗

Anti-Proliferative and Pro-Apoptotic Activities of Synthesized 3,4,5 Tri-Methoxy Ciprofloxacin Chalcone Hybrid, through p53 Up-Regulation in HepG2 and MCF7 Cell LinesSemantic proximity Read ↗

Blueberry anthocyanin induces apoptosis in HepG-2 cells and the mechanism of the processSemantic proximity Read ↗

Melilotus indicus extract induces apoptosis in hepatocellular carcinoma cells via a mechanism involving mitochondria-mediated pathwaysSemantic proximity Read ↗

Apoptosis induction in human hepatoma cell line HepG2 cells by trans- Anethole via activation of mitochondria-mediated apoptotic pathwaysSemantic proximity Read ↗

Induction of apoptosis in human leukemia cells through an intrinsic pathway by cathachunine, a unique alkaloid isolated from Catharanthus roseusSemantic proximity Read ↗

Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell linesSemantic proximity Read ↗

Cytotoxic Potential of Crataegus orientalis Fruit Extract: Expression Profiles of Apoptosis - Related Genes (Bax, Bcl2, p53)Semantic proximity Read ↗

Antitumor Effects of Dihydromyricetin on the Proliferation, Migration and Apoptosis of Human Hepatocellular Carcinoma Hep3B CellsSemantic proximity Read ↗

Avenanthramide-C reduces the viability of MDA-MB-231 breast cancer cells through an apoptotic mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.