Article
The impact of maternal plasma DNA fetal fraction on next generation sequencing tests for common fetal aneuploidies
16 Apr 2013
Abstract excerpt
Maternal plasma contains circulating cell-free DNA fragments originating from both the mother and the placenta. The proportion derived from the placenta is known as the fetal fraction. When measured between 10 and 20 gestational weeks, the average fetal fraction in the maternal plasma is 10% to 15% but can range from under 3% to over 30%. Screening performance using next-generation sequencing of circulating...
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