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Article

Population pharmacokinetics analysis of cyclophosphamide with genetic effects in patients undergoing hematopoietic stem cell transplantation.

European journal of clinical pharmacology - 1 Aug 2013

Kim In-Wha, Yun Hwi-yeol, Choi Boyoon, Han Nayoung, Kim Myeong Gyu, Park Seonyang, Oh Jung Mi

Abstract excerpt

PURPOSE: To build a population pharmacokinetic (PK) model of cyclophosphamide (CY) and its metabolite, 4-hydroxycyclophosphamide (HCY), in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) and to identify covariates, including genetic polymorphisms, which affect CY and HCY PK parameters. METHOD: The study cohort comprised 21 patients undergoing HSCT who received CY intravenously...

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Identifiers

PMID: 23588565
DOI: 10.1007/s00228-013-1507-7

Genes

ABCC2
ABCB1
GSTA1
GSTM1
GSTP1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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