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Article

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish.

Disease models & mechanisms - 1 Jul 2013

Kim Seok-Hyung, Kowalski Marie L, Carson Robert P, Bridges L Richard, Ess Kevin C

Abstract excerpt

Tuberous sclerosis complex (TSC) is a multi-organ disorder caused by mutations of the TSC1 or TSC2 genes. A key function of these genes is to inhibit mTORC1 (mechanistic target of rapamycin complex 1) kinase signaling. Cells deficient for TSC1 or TSC2 have increased mTORC1 signaling and give rise to benign tumors, although, as a rule, true malignancies are rarely seen. In contrast, other disorders with increased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23580196
DOI: 10.1242/dmm.011494
PMCID: PMC3701212

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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