Article
Randomised phase II trial (NCT00637975) evaluating activity and toxicity of two different escalating strategies for pregabalin and oxycodone combination therapy for neuropathic pain in cancer patients.
PloS one - 1 Jan 2013
Garassino Marina Chiara, Piva Sheila, La Verde Nicla, Spagnoletti Ilaria, Iorno Vittorio, Carbone Claudia, Febbraro Antonio, Bianchi Anna, Bramati Annalisa, Moretti Anna, Ganzinelli Monica, Marabese Mirko, Gentili Marta, Torri Valter, Farina Gabriella
Abstract excerpt
PURPOSE: Neuropathic pain is commonly associated with cancer. Current treatments include combination opioid and adjuvant therapies, but no guidelines are available for dose escalation strategies. This phase II study compared the efficacy and tolerability of two dose escalation strategies for oxycodone and pregabalin combination therapy. METHODS: Patients (N = 75) with oncological neuropathic pain, previously...
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