Article
Detection of ABL1 kinase mutations in Philadelphia-positive patients exhibiting an inadequate molecular response using restriction fragment mass polymorphism and its clinical significance: a single-center experience in Korea.
International journal of laboratory hematology - 1 Dec 2013
Cho Y-U, Kim S-O, Chi H-S, Park S-J, Jang S, Park C-J, Seo E-J, Lee J-H, Lee J-H, Lee K-H, Im H-J, Seo J-J, Hong S P
Abstract excerpt
INTRODUCTION: ABL1 kinase mutations represent a major mechanism of imatinib resistance in Philadelphia-positive (Ph+) patients. There is a paucity of data on ABL1 kinase mutations in Ph+ patients in Korea. METHODS: We used restriction fragment mass polymorphism (RFMP) analysis to detect ABL1 kinase mutations in blood or bone marrow specimens from 80 Ph+ patients. RESULTS: Fifty-seven patients met the criteria for...
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