Article
Identification of rodent homologs of hepatitis C virus and pegiviruses.
mBio - 9 Apr 2013
Kapoor Amit, Simmonds Peter, Scheel Troels K H, Hjelle Brian, Cullen John M, Burbelo Peter D, Chauhan Lokendra V, Duraisamy Raja, Sanchez Leon Maria, Jain Komal, Vandegrift Kurt Jason, Calisher Charles H, Rice Charles M, Lipkin W Ian
Abstract excerpt
UNLABELLED: Hepatitis C virus (HCV) and human pegivirus (HPgV or GB virus C) are globally distributed and infect 2 to 5% of the human population. The lack of tractable-animal models for these viruses, in particular for HCV, has hampered the study of infection, transmission, virulence, immunity, and pathogenesis. To address this challenge, we searched for homologous viruses in small mammals, including wild...
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