Article
Hepatitis C virus RNA recombination in cell culture.
Journal of hepatology - 1 Oct 2011
Reiter Jochen, Pérez-Vilaró Gemma, Scheller Nicoletta, Mina Leonardo Bruno, Díez Juana, Meyerhans Andreas
Abstract excerpt
BACKGROUND & AIMS: The Hepatitis C virus (HCV) exhibits large genetic diversity, both on a global scale and at the level of the infected individual. A major underlying mechanism of the observed sequence differences is error-prone virus replication by the viral RNA polymerase NS5B. In addition, based on phylogenetic comparisons of patient-derived HCV sequences, there is evidence of HCV recombination. However, to...
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