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Frogs and estivation: transcriptional insights into metabolism and cell survival in a natural model of extended muscle disuse

3 Apr 2013

Abstract excerpt

Green-striped burrowing frogs (Cyclorana alboguttata) survive in arid environments by burrowing underground and entering into a deep, prolonged metabolic depression known as estivation. Throughout estivation, C. alboguttata is immobilized within a cast-like cocoon of shed skin and ceases feeding and moving. Remarkably, these frogs exhibit very little muscle atrophy despite extended disuse and fasting. Little is...

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PMID: 23548685
DOI: 10.1152/physiolgenomics.00163.2012

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