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Article

Neural mechanisms underlying heterogeneity in the presentation of anxious temperament.

Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013

Shackman Alexander J, Fox Andrew S, Oler Jonathan A, Shelton Steven E, Davidson Richard J, Kalin Ned H

Abstract excerpt

Children with an anxious temperament (AT) are at risk for developing psychiatric disorders along the internalizing spectrum, including anxiety and depression. Like these disorders, AT is a multidimensional phenotype and children with extreme anxiety show varying mixtures of physiological, behavioral, and other symptoms. Using a well-validated juvenile monkey model of AT, we addressed the degree to which this...

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Identifiers

PMID: 23538303
DOI: 10.1073/pnas.1214364110
PMCID: PMC3625282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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