Article
The N terminus of orf virus-encoded protein 002 inhibits acetylation of NF-κB p65 by preventing Ser(276) phosphorylation.
PloS one - 1 Jan 2013
Ning Zhangyong, Zheng Zewei, Hao Wenbo, Duan Chaohui, Li Wei, Wang Yuanyuan, Li Ming, Luo Shuhong
Abstract excerpt
Orf virus-encoded protein 002 (ORFV002) inhibits NF-κB signaling pathway by decreasing the acetylation of NF-κB-p65 through interference of NF-κB p65's association with NF-κB p300. However, the precise mechanism of how ORFV002 interferes with the NF-κB p65/p300 association is still unknown. Due to similarities of the amino acid sequences of ORFV002 and the adenovirus type 12 (Ad12) E1A protein (E1A-12), we...
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