Article
Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells.
Nature communications - 1 Jan 2013
Polson Euan S, Lewis John L, Celik Hamza, Mann Vincent M, Stower Michael J, Simms Matthew S, Rodrigues Greta, Collins Anne T, Maitland Norman J
Abstract excerpt
While chromosomal translocations have a fundamental role in the development of several human leukaemias, their role in solid tumour development has been somewhat more controversial. Recently, it was shown that up to 80% of prostate tumours harbour at least one such gene fusion, and that the most common fusion event, between the prostate-specific TMPRSS2 gene and the ERG oncogene, is a critical, and probably early...
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