Article
Therapeutic angiogenesis for the critical limb ischemia decreases platelet activation.
Platelets - 1 Jan 2014
Chudý Peter, Chudá Daniela, Hudeček Jan, Fedorová Jana, Sinák Igor, Hlinka Luboš, Talapková Renáta, Laca Ludovít, Kubisz Peter
Abstract excerpt
Platelets are required for the recruitment of bone marrow-derived mononuclear cells (BMMNC) into ischemia-induced vasculature, which underlines their key role in angiogenesis. The difference in platelet immunophenotype between healthy controls and patients with critical limb ischemia (CLI) treated with therapeutic angiogenesis (TA) using BMMNC was assessed. The impact of TA on the expression of platelet membrane...
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