Article
[The effect of genetic factors on the phenotypic expression of multiple sclerosis].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2013
Korobko D S, Malkova N A, Bulatova E V, Babenko L A, Sazonov D V, Sokolova E A, Filipenko M L
Abstract excerpt
A total of 326 patients with multiple sclerosis (MS) according to the McDonald criteria (2005) were recruited to the study. Single nucleotide polymorphisms in the CD40 gene (rs6074022, rs1883832, rs1535045 and rs11086998) and the KIF1B gene (rs10492972 and rs3135388) were genotyped using TaqMan technology. We found a significant association of (risk allele T, OR=1.74, 95% CI 1.34-2.32, p=2.96·10-7) and...