Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer.

PloS one - 1 Jan 2013

Barrett Christian L, Schwab Richard B, Jung HyunChul, Crain Brian, Goff Daniel J, Jamieson Catriona H M, Thistlethwaite Patricia A, Harismendy Olivier, Carson Dennis A, Frazer Kelly A

Abstract excerpt

BACKGROUND: The only therapeutic options that exist for squamous cell lung carcinoma (SCC) are standard radiation and cytotoxic chemotherapy. Cancer stem cells (CSCs) are hypothesized to account for therapeutic resistance, suggesting that CSCs must be specifically targeted. Here, we analyze the transcriptome of CSC and non-CSC subpopulations by RNA-seq to identify new potential therapeutic strategies for SCC....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AC133 Antigen
Share to Antigens, CD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to DNA Copy Number Variations

Share to Glycoproteins

Share to Neoplastic Stem Cells

Share to RNA, Neoplasm

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 23527012
DOI: 10.1371/journal.pone.0058714
PMCID: PMC3604164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancer.PMID 23527012Read ↗

Squamous cell lung cancer: from tumor genomics to cancer therapeutics.Semantic proximity Read ↗

Characterization of Cancer Stem Cells in Laryngeal Squamous Cell Carcinoma by Single-Cell RNA SequencingSemantic proximity Read ↗

Characterization of Cancer Stem Cells in Laryngeal Squamous Cell Carcinoma by Single-cell RNA SequencingSemantic proximity Read ↗

New strategies in squamous cell carcinoma of the lung: identification of tumor drivers to personalize therapy.Semantic proximity Read ↗

Genomic and transcriptomic profiling of combined small-cell lung cancer through microdissection: unveiling the transformational pathway of mixed subtypeSemantic proximity Read ↗

An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.Semantic proximity Read ↗

Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cellsSemantic proximity Read ↗

Clinical applications of The Cancer Genome Atlas project (TCGA) for squamous cell lung carcinoma.Semantic proximity Read ↗

Targeted therapies for locally advanced or metastatic squamous cell carcinoma of the lung.Semantic proximity Read ↗

Development of a Circulating Tumour Cell Culture Model from Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targetsSemantic proximity Read ↗

Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.