Article
Detection of two equine trisomies using SNP-CGH.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2013
Holl Heather M, Lear Teri L, Nolen-Walston Rose D, Slack Joann, Brooks Samantha A
Abstract excerpt
Chromosomal aberrations in the horse are known to cause congenital abnormalities, embryonic loss, and infertility. While diagnosed mainly by karyotyping and FISH in the horse, the use of SNP array comparative genome hybridization (SNP-CGH) is becoming increasingly common in human diagnostics. Normalized probe intensities and allelic ratios are used to detect changes in copy number genome-wide. Two horses with...
Topics
- Animals
- Chromosome Aberrations
- Chromosome Disorders
- Chromosomes, Mammalian
- Comparative Genomic Hybridization
- Female
- Horse Diseases
- Horses
- Male
- Polymorphism, Single Nucleotide
- Trisomy