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Article

Functional analysis of the single nucleotide polymorphism (787T>C) in the tissue-nonspecific alkaline phosphatase gene associated with BMD.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2005

Goseki-Sone Masae, Sogabe Natsuko, Fukushi-Irie Mariko, Mizoi Lena, Orimo Hideo, Suzuki Takao, Nakamura Hiroyuki, Orimo Hajime, Hosoi Takayuki

Abstract excerpt

UNLABELLED: Polymorphisms of the TNSALP gene have not previously been studied as a possible determinant for variations in BMD or as a predisposing genetic factor for osteoporosis. This study showed a significantly higher association between the 787T>C (Tyr246His) TNSALP gene and BMD among 501 postmenopausal women. Furthermore, the effects of amino acid substitution on the catalytic property of the protein...

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Identifiers

PMID: 15824850
DOI: 10.1359/JBMR.041229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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