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Article

Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response.

Proceedings of the National Academy of Sciences of the United States of America - 2 Apr 2013

Mishiba Kei-ichiro, Nagashima Yukihiro, Suzuki Eiji, Hayashi Noriko, Ogata Yoshiyuki, Shimada Yukihisa, Koizumi Nozomu

Abstract excerpt

The unfolded protein response (UPR) is a cellular response highly conserved in eukaryotes to obviate accumulation of misfolded proteins in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 (IRE1) catalyzes the cytoplasmic splicing of mRNA encoding bZIP transcription factors to activate the UPR signaling pathway. Arabidopsis IRE1 was recently shown to be involved in the cytoplasmic splicing of bZIP60...

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Identifiers

PMID: 23509268
DOI: 10.1073/pnas.1219047110
PMCID: PMC3619347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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