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Article

[Driver gene mutation and targeted therapy of lung cancer].

Gan to kagaku ryoho. Cancer & chemotherapy - 1 Mar 2013

Mitsudomi Tetsuya

Abstract excerpt

Although cancers may have many genetic alterations, there are only a few mutations actually associated with essential traits of cancer cells such as cell proliferation or evasion from apoptosis. Because cancer cells are "addicted" to these "drive genes" , pharmacologic inhibition of these gene function is highly effective. Epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitor(TKI)(such as gefitinib or...

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Source

Identifiers

PMID: 23507588

Genes

EGFR
ALK
RET
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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