Article
Genetic predisposition to higher blood pressure increases coronary artery disease risk.
Hypertension (Dallas, Tex. : 1979) - 1 May 2013
Lieb Wolfgang, Jansen Henning, Loley Christina, Pencina Michael J, Nelson Christopher P, Newton-Cheh Christopher, Kathiresan Sekar, Reilly Muredach P, Assimes Themistocles L, Boerwinkle Eric, Hall Alistair S, Hengstenberg Christian, Laaksonen Reijo, McPherson Ruth, Thorsteinsdottir Unnur, Ziegler Andreas, Peters Annette, Thompson John R, König Inke R, Erdmann Jeanette, Samani Nilesh J, Vasan Ramachandran S, Schunkert Heribert
Abstract excerpt
Hypertension is a risk factor for coronary artery disease. Recent genome-wide association studies have identified 30 genetic variants associated with higher blood pressure at genome-wide significance (P<5 × 10(-8)). If elevated blood pressure is a causative factor for coronary artery disease, these variants should also increase coronary artery disease risk. Analyzing genome-wide association data from 22 233...
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