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Article

Impact of sequence diversity in the Moraxella catarrhalis UspA2/UspA2H head domain on vitronectin binding and antigenic variation.

Microbes and infection - 1 May 2013

Su Yu-Ching, Hallström Björn M, Bernhard Sara, Singh Birendra, Riesbeck Kristian

Abstract excerpt

The nasopharyngeal pathogen Moraxella catarrhalis recruits vitronectin to subvert complement-mediated killing. Ubiquitous surface protein (UspA) 2 and its hybrid form UspA2H bind vitronectin at the highly diverse N-terminal head domain. Here we characterized the sequence diversity of the head domain in multiple M. catarrhalis clinical isolates (n = 51) with focus on binding of vitronectin. The head domain of the...

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Identifiers

PMID: 23474333
DOI: 10.1016/j.micinf.2013.02.004

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