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Article

To charge or not to charge: mechanistic insights into neuropathy-associated tRNA synthetase mutations.

Current opinion in genetics & development - 1 Jun 2013

Wallen Rachel C, Antonellis Anthony

Abstract excerpt

Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes responsible for the first step of protein translation--attaching amino acids to cognate tRNA molecules. Interestingly, ARS gene mutations have been implicated in tissue-specific human diseases, including inherited peripheral neuropathies. To date, five loci encoding an ARS have been implicated in peripheral neuropathy, and alleles at...

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Identifiers

PMID: 23465884
DOI: 10.1016/j.gde.2013.02.002
PMCID: PMC3703498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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