Article
Do mitochondria contribute to left ventricular non-compaction cardiomyopathy? New findings from myocardium of patients with left ventricular non-compaction cardiomyopathy.
Molecular genetics and metabolism - 1 May 2013
Liu Shenghua, Bai Yuanyuan, Huang Jie, Zhao Hong, Zhang Xiaoling, Hu Shengshou, Wei Yingjie
Abstract excerpt
BACKGROUND: Left ventricular non-compaction cardiomyopathy (LVNC) is a rare congenital cardiomyopathy that is associated with mutations in mitochondrial DNA (mtDNA), however, no study of myocardium mtDNA of LVNC patients has been reported. To identify novel candidate mtDNA variants that may be responsible for the pathogenesis of LVNC, myocardial specimens were examined to investigate pathogenic mtDNA variants....
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