Article
Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2013
Walker A Sarah, Eyre David W, Wyllie David H, Dingle Kate E, Griffiths David, Shine Brian, Oakley Sarah, O'Connor Lily, Finney John, Vaughan Alison, Crook Derrick W, Wilcox Mark H, Peto Tim E A
Abstract excerpt
BACKGROUND: Despite substantial interest in biomarkers, their impact on clinical outcomes and variation with bacterial strain has rarely been explored using integrated databases. METHODS: From September 2006 to May 2011, strains isolated from Clostridium difficile toxin enzyme immunoassay (EIA)-positive fecal samples from Oxfordshire, United Kingdom (approximately 600,000 people) underwent multilocus sequence...
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