Correlation between global genome methylation and mutation at CpG codons of p53 gene.

Abstract excerpt

OBJECTIVE: Hypomethylation within the body of the p53 gene, which is normally methylated, has been found in neoplasms. Also, the CG → TA transition was not detected in the CpG codons of the p53 gene in gastritis lesions in Iranian patients. Therefore, an evaluation of the probable correlation between global genome methylation and alteration at CpG codons of p53 gene was needed. METHODS: For defining the genotypes...

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