Article
Aberrant gene expression in dogs with portosystemic shunts.
PloS one - 1 Jan 2013
van Steenbeek Frank G, Van den Bossche Lindsay, Grinwis Guy C M, Kummeling Anne, van Gils Ingrid H M, Koerkamp Marian J A Groot, van Leenen Dik, Holstege Frank C P, Penning Louis C, Rothuizen Jan, Leegwater Peter A J, Spee Bart
Abstract excerpt
Congenital portosystemic shunts are developmental anomalies of the splanchnic vascular system that cause portal blood to bypass the liver. Large-breed dogs are predisposed for intrahepatic portosystemic shunts (IHPSS) and small-breed dogs for extrahepatic portosystemic shunts (EHPSS). While the phenotype resulting from portal bypass of the liver of the two types of shunt is identical, the genotype and molecular...
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