Article
No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis.
Annals of neurology - 1 Mar 2013
Ban Maria, Caillier Stacy, Mero Inger-Lise, Myhr Kjell-Morten, Celius Elisabeth G, Aarseth Jan, Torkildsen Øivind, Harbo Hanne F, Oksenberg Jorge, Hauser Stephen L, Sawcer Stephen, Compston Alastair
Abstract excerpt
An association has previously been reported between susceptibility to multiple sclerosis and the rare mutant alleles of the CYP27B1 gene responsible for autosomal recessive vitamin D-dependent rickets type 1 (VDDR1). In an attempt to replicate this finding, we screened 495 multiplex families and 2,092 single affected families, together with 4,594 cases and 3,583 controls (a total of 17,073 individuals) but were...
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