Article
Rare variants in the CYP27B1 gene are associated with multiple sclerosis.
Annals of neurology - 1 Dec 2011
Ramagopalan Sreeram V, Dyment David A, Cader M Zameel, Morrison Katie M, Disanto Giulio, Morahan Julia M, Berlanga-Taylor Antonio J, Handel Adam, De Luca Gabriele C, Sadovnick A Dessa, Lepage Pierre, Montpetit Alexandre, Ebers George C
Abstract excerpt
OBJECTIVE: Multiple sclerosis (MS) is a complex neurological disease. Genetic linkage analysis and genotyping of candidate genes in families with 4 or more affected individuals more heavily loaded for susceptibility genes has not fully explained familial disease clustering. METHODS: We performed whole exome sequencing to further understand the heightened prevalence of MS in these families. RESULTS: Forty-three...
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