Article
Computational analysis of KRAS mutations: implications for different effects on the KRAS p.G12D and p.G13D mutations.
PloS one - 1 Jan 2013
Chen Chih-Chieh, Er Tze-Kiong, Liu Yen-Yi, Hwang Jenn-Kang, Barrio Maria Jesus, Rodrigo Maximiliano, Garcia-Toro Enrique, Herreros-Villanueva Marta
Abstract excerpt
BACKGROUND: The issue of whether patients diagnosed with metastatic colorectal cancer who harbor KRAS codon 13 mutations could benefit from the addition of anti-epidermal growth factor receptor therapy remains under debate. The aim of the current study was to perform computational analysis to investigate the structural implications of the underlying mutations caused by c.38G>A (p.G13D) on protein conformation....
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