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Autophagy in ageing and ageing-associated diseases

18 Feb 2013

Abstract excerpt

Autophagy is a cell self-digestion process via lysosomes that clears "cellular waste", including aberrantly modified proteins or protein aggregates and damaged organelles. Therefore, autophagy is considered a protein and organelle quality control mechanism that maintains normal cellular homeostasis. Dysfunctional autophagy has been observed in ageing tissues and several ageing-associated diseases. Lifespan of...

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PMID: 23416930
DOI: 10.1038/aps.2012.188

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