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Article

PLAG1 and CYLD do not play a role in the tumorigenesis of adenoid cystic carcinoma.

Molecular medicine reports - 1 Apr 2013

Daa Tsutomu, Nakamura Itaru, Yada Naomi, Arakane Shigeki, Nishida Haruto, Kashima Kenji, Suzuki Masashi, Yokoyama Shigeo

Abstract excerpt

The pleiomorphic adenoma gene 1 (PLAG1) gene is activated in a subset of pleomorphic adenomas of the salivary gland by gene fusion. Germ‑line mutation in cylindromatosis (CYLD), a tumor suppressor gene, causes familial cylindromatosis and Brook‑Spiegler syndrome. In the present study, aberrations in PLAG1 and CYLD were investigated in adenoid cystic carcinoma (ACC) of the salivary gland. Reverse‑transcription PCR...

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Topics

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Share to Carcinogenesis
Share to Carcinoma, Adenoid Cystic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deubiquitinating Enzyme CYLD

Share to DNA-Binding Proteins

Share to Mutation

Share to Oncogene Proteins, Fusion

Share to Salivary Glands

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Source

Identifiers

PMID: 23404581
DOI: 10.3892/mmr.2013.1311

Genes

CYLD
PLAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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