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Article

Aggressive transformation of juvenile myelomonocytic leukemia associated with duplication of oncogenic KRAS due to acquired uniparental disomy.

The Journal of pediatrics - 1 Jun 2013

Kato Motohiro, Yasui Naoko, Seki Masafumi, Kishimoto Hiroshi, Sato-Otsubo Aiko, Hasegawa Daisuke, Kiyokawa Nobutaka, Hanada Ryoji, Ogawa Seishi, Manabe Atsushi, Takita Junko, Koh Katsuyoshi

Abstract excerpt

A small fraction of cases of juvenile myelomonocytic leukemia (JMML) develop massive disease activation. Through genomic analysis of JMML, which developed in an individual with mosaicism for oncogenic KRAS mutation with rapid progression, we identified acquired uniparental disomy at 12p. We demonstrated that duplication of oncogenic KRAS is associated with rapid JMML progression.

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Share to Leukemia, Myelomonocytic, Juvenile

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23403250
DOI: 10.1016/j.jpeds.2013.01.003

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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