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Article

Peroxisome proliferator-activated receptor-γ mutations responsible for lipodystrophy with severe hypertension activate the cellular renin-angiotensin system.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2013

Auclair Martine, Vigouroux Corinne, Boccara Franck, Capel Emilie, Vigeral Catherine, Guerci Bruno, Lascols Olivier, Capeau Jacqueline, Caron-Debarle Martine

Abstract excerpt

OBJECTIVE: Inactivating peroxisome proliferator-activated receptor-γ (PPARγ) mutations lead to a syndrome of familial partial lipodystrophy (FPLD3) associated with early-onset severe hypertension. PPARγ can repress the vascular renin-angiotensin system (RAS) and angiotensin II receptor 1 expression. We evaluated the relationships between PPARγ inactivation and cellular RAS using FPLD3 patients' cells and human...

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Source

Identifiers

PMID: 23393388
DOI: 10.1161/ATVBAHA.112.300962

Genes

PPARG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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