Article
Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation study.
Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2013
Björkhem-Bergman Linda, Nylén Hanna, Norlin Anna-Carin, Lindh Jonatan D, Ekström Lena, Eliasson Erik, Bergman Peter, Diczfalusy Ulf
Abstract excerpt
The primary aim was to study the relationship between individual serum levels of 25-hydroxyvitamin D and 4β-hydroxycholesterol, which is an endogenous biomarker of the drug-metabolizing CYP3A enzymes. In addition, the relationship between this biomarker and inflammation, measured as C-reactive protein (CRP), was investigated. Serum samples were used from a recently performed clinical trial in patients with...
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