Article
The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate.
The FEBS journal - 1 Apr 2013
Ferraroni Marta, Matera Irene, Bürger Sibylle, Reichert Sabrina, Steimer Lenz, Scozzafava Andrea, Stolz Andreas, Briganti Fabrizio
Abstract excerpt
UNLABELLED: The salicylate 1,2-dioxygenase (SDO) from the bacterium Pseudaminobacter salicylatoxidans BN12 is a versatile gentisate 1,2-dioxygenase (GDO) that converts both gentisate (2,5-dihydroxybenzoate) and various monohydroxylated substrates. Several variants of this enzyme were rationally designed based on the previously determined enzyme structure and sequence differences between the SDO and the...
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