Article
21-Hydroxylase gene mutant allele CYP21A2*15 strongly linked to the resistant HLA haplotype B*14:02-DRB1*01:02 in chronic Chagas disease.
Human immunology - 1 Jun 2013
del Puerto Florencia, Kikuchi Mihoko, Nishizawa Juan Eiki, Roca Yelin, Avila Cinthia, Gianella Alberto, Lora Javier, Gutierrez Velarde Freddy Udalrico, Hirayama Kenji
Abstract excerpt
We previously reported protective haplotype HLA-B*14:02-DRB1*01:02 against chronic Chagas disease in Bolivia. The V281L mutant allele of the 21-Hydroxylase gene, CYP21A2*15, is reported to be located in the Class III region of the Human leukocyte antigen region and linked to the haplotype HLA-B*14:02-DRB1*01:02. The mutant allele might play a primary role in the pathogenesis of chronic Chagas disease in the...
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