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Article

Exome sequencing identifies novel rheumatoid arthritis-susceptible variants in the BTNL2.

Journal of human genetics - 1 Apr 2013

Mitsunaga Shigeki, Hosomichi Kazuyoshi, Okudaira Yuko, Nakaoka Hirofumi, Kunii Nanae, Suzuki Yasuo, Kuwana Masataka, Sato Shinji, Kaneko Yuko, Homma Yasuhiko, Kashiwase Koichi, Azuma Fumihiro, Kulski Jerzy K, Inoue Ituro, Inoko Hidetoshi

Abstract excerpt

The butyrophilin-like protein 2 gene (BTNL2) within the class III region of the major histocompatibility complex genomic region was identified as a rheumatoid arthritis (RA) susceptibility gene by exome sequencing (19 RA cases) with stepwise filtering analysis, and then validated by Sanger sequencing and association analysis using 432 cases and 432 controls. Logistic regression of the Sanger-sequenced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23364395
DOI: 10.1038/jhg.2013.2

Genes

BTNL2
NOTCH4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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