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Article

Uncovering novel biomarkers and drug targets for androgenetic alopecia via metabolite regulation and multi-tissue validation.

Free radical biology & medicine - 1 Feb 2026

Yi Sha, Liu Aimei, Zhang Xinyue, Deng Yongqiong, Chen Yan, Huoshen Wuda

Abstract excerpt

BACKGROUND: Androgenetic alopecia (AGA) is the most common form of hair loss globally. Despite its prevalence, only two FDA-approved drugs-minoxidil and finasteride-are currently available, underscoring the urgent need to discover novel biomarkers and therapeutic targets for AGA diagnosis, treatment, and monitoring. OBJECTIVES: This study aimed to explore novel therapeutic targets and biomarkers for AGA and...

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Source

Identifiers

PMID: 41285252
DOI: 10.1016/j.freeradbiomed.2025.11.053

Genes

AGA
KL
SOD1
ADM
BRAF
LAMC1
LAMC3
NT5E
PAM
PRLR
SQLE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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