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Article

Nonself recognition through intermolecular disulfide bond formation of ribonucleotide reductase in neurospora.

Genetics - 1 Apr 2013

Smith Robert P, Wellman Kenji, Haidari Leila, Masuda Hirohisa, Smith Myron L

Abstract excerpt

Type I ribonucleotide reductases (RNRs) are conserved across diverse taxa and are essential for the conversion of RNA into DNA precursors. In Neurospora crassa, the large subunit of RNR (UN-24) is unusual in that it also has a nonself recognition function, whereby coexpression of Oak Ridge (OR) and Panama (PA) alleles of un-24 in the same cell leads to growth inhibition and cell death. We show that coexpressing...

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Identifiers

PMID: 23335337
DOI: 10.1534/genetics.112.147405
PMCID: PMC3606095

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Source receipt: pubmed, retrieved 7 Sept 2026.

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