Article
Non-autoimmune subclinical hypothyroidism due to a mutation in TSH receptor: report on two brothers.
Italian journal of pediatrics - 19 Jan 2013
Cerbone Manuela, Agretti Patrizia, De Marco Giuseppina, Improda Nicola, Pignata Claudio, Santamaria Francesca, Tonacchera Massimo, Salerno Mariacarolina
Abstract excerpt
Subclinical hypothyroidism (SH) is a condition characterized by a mild persistent thyroid failure. The main cause is represented by autoimmune thyroiditis, but mutations in genes encoding proteins involved in TSH pathway are thought to be responsible for SH, particularly in cases arising in familial settings. Patients with the syndrome of TSH unresponsiveness may have compensated or overt hypothyroidism with a...
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