Article
CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control.
Drug metabolism and drug interactions - 1 Jan 2013
Kitzmiller Joseph Paul, Sullivan Danielle M, Phelps Mitchell A, Wang Danxin, Sadee Wolfgang
Abstract excerpt
BACKGROUND: Statins are indicated for prevention of atherosclerotic cardiovascular disease. Metabolism of certain statins involves the cytochrome P450 3A (CYP3A) enzymes, and CYP3A4*22 significantly influences the dose needed for achieving optimal lipid control for atorvastatin, simvastatin, and...
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