Article
Evaluation of targeted next-generation sequencing-based preimplantation genetic diagnosis of monogenic disease.
Fertility and sterility - 1 Apr 2013
Treff Nathan R, Fedick Anastasia, Tao Xin, Devkota Batsal, Taylor Deanne, Scott Richard T
Abstract excerpt
OBJECTIVE: To investigate the applicability of next-generation sequencing (NGS) to preimplantation genetic diagnosis (PGD); to evaluate semiconductor-based NGS for genetic analysis of human embryos. DESIGN: Blinded. SETTING: Academic center for reproductive medicine. PATIENT(S): Six couples at risk of transmitting single-gene disorders to their offspring. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Embryonic...
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