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Article

Meiotic sex chromosome inactivation is disrupted in sterile hybrid male house mice.

Genetics - 1 Mar 2013

Campbell Polly, Good Jeffrey M, Nachman Michael W

Abstract excerpt

In male mammals, the X and Y chromosomes are transcriptionally silenced in primary spermatocytes by meiotic sex chromosome inactivation (MSCI) and remain repressed for the duration of spermatogenesis. Here, we test the longstanding hypothesis that disrupted MSCI might contribute to the preferential sterility of heterogametic hybrid males. We studied a cross between wild-derived inbred strains of Mus musculus...

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Identifiers

PMID: 23307891
DOI: 10.1534/genetics.112.148635
PMCID: PMC3584000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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