Article
The apoptotic effects of toosendanin are partially mediated by activation of deoxycytidine kinase in HL-60 cells.
PloS one - 1 Jan 2012
Ju Jianming, Qi Zhichao, Cai Xueting, Cao Peng, Huang Yan, Wang Shuzhen, Liu Nan, Chen Yijun
Abstract excerpt
Triterpenoid toosendanin (TSN) exhibits potent cytotoxic activity through inducing apoptosis in a variety of cancer cell lines. However, the target and mechanism of the apoptotic effects by TSN remain unknown. In this study, we captured a specific binding protein of TSN in HL-60 cells by serial affinity chromatography and further identified it as deoxycytidine kinase (dCK). Combination of direct activation of dCK...
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