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On the measurements of genetic differentiation among populations.

Genetics research - 1 Oct 2012

Wang J

Abstract excerpt

F(ST), a measurement of the genetic differentiation among subpopulations, is a fundamental parameter in population genetics, with many valuable applications in molecular biology, evolutionary biology, conservation and forensics. One of its close relatives, G(ST), has been widely used to measure differentiation from highly polymorphic markers such as microsatellites. However, because of the high mutation rate of...

Topics

Biological Evolution
Genetic Drift
Genetic Markers
Genetic Variation
Genetics, Population
Genotype
Humans
Microsatellite Repeats
Models, Genetic
Mutation
Mutation Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23298450
DOI: 10.1017/S0016672312000481

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On the measurements of genetic differentiation among populations.PMID 23298450Read ↗

G(ST) and its relatives do not measure differentiation.Semantic proximity Read ↗

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If F(ST) does not measure neutral genetic differentiation, then comparing it with Q(ST) is misleading. Or is it?Semantic proximity Read ↗

Does GST underestimate genetic differentiation from marker data?Semantic proximity Read ↗

What is genetic differentiation, and how should we measure it--GST, D, neither or both?Semantic proximity Read ↗

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Relationship between three measures of genetic differentiation G(ST), D(EST) and G'(ST): how wrong have we been?Semantic proximity Read ↗

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