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Article

Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.

Journal of medicinal chemistry - 14 Feb 2013

Zhang Hongmei, Wang Yuan-Fang, Shen Chen-Hsiang, Agniswamy Johnson, Rao Kalapala Venkateswara, Xu Chun-Xiao, Ghosh Arun K, Harrison Robert W, Weber Irene T

Abstract excerpt

GRL-0519 (1) is a potent antiviral inhibitor of HIV-1 protease (PR) possessing tris-tetrahydrofuran (tris-THF) at P2. The high resolution X-ray crystal structures of inhibitor 1 in complexes with single substitution mutants PR(R8Q), PR(D30N), PR(I50V), PR(I54M), and PR(V82A) were analyzed in relation to kinetic data. The smaller valine side chain in PR(I50V) eliminated hydrophobic interactions with inhibitor and...

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Identifiers

PMID: 23298236
DOI: 10.1021/jm301519z
PMCID: PMC3574189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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