Article
P2 domain profiles and shedding dynamics in prospectively monitored norovirus outbreaks.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Apr 2013
Sukhrie Faizel H A, Teunis Peter, Vennema Harry, Bogerman Jolanda, van Marm Sebastian, Beersma Matthias F C Thijs, Koopmans Marion
Abstract excerpt
BACKGROUND: Norovirus P2 domain is commonly used to extrapolate transmission within an outbreak (OB) setting. The current definition is that transmission among cases is considered to be proven when no sequence variation is found. OBJECTIVES: Previous studies have shown a high mutation rate and errors during replication of the norovirus genome, therefore the validity of this criterion must be evaluated. STUDY...
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