Article
Transmission events within outbreaks of gastroenteritis determined through analysis of nucleotide sequences of the P2 domain of genogroup II noroviruses.
Journal of clinical microbiology - 1 Mar 2008
Xerry Jacqueline, Gallimore Chris I, Iturriza-Gómara Miren, Allen David J, Gray Jim J
Abstract excerpt
Tracking the spread of noroviruses during outbreaks of gastroenteritis is hampered by the lack of sequence diversity in those regions of the genome chosen for virus detection and characterization. Sequence analysis of regions of the genes encoding the RNA-dependent RNA polymerase and the S domain of the capsid does not provide sufficient discrimination between genotypically related strains of different outbreaks....
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